Current Issue

Featured article

Immunotherapy of myositis: issues, concerns and future prospects

Marinos C. Dalakas

In this Review, the author discusses therapeutic principles that guide the treatment of myositis, in the context of issues including clinical presentation, diagnostic procedures, and practical approaches to treatment. Insights into the immunopathogenesis of myositis and the emergence of new therapeutic agents are also reviewed.

Current Issue

Featured article

RA: lowering cardiovascular risk with statins

Justin M. S. Lee & Robin P. Choudhury

Common involvement of inflammation can account in part for the strong association between rheumatoid arthritis and cardiovascular disease. Statins have both lipid-modifying and anti-inflammatory effects and are established in the general prevention and treatment of cardiovascular disease; their role in rheumatoid arthritis, however, is only more recently being explored.

Current Issue

Also in this issue

• News & Views: Belimumab for systemic lupus erythematosus: breaking through?

• News & Views: Assessing cancer risk of cytokine inhibitors in RA

• News & Views: Inducing remission in ANCA-positive vasculitis: time to RAVE?

Current Issue

Also in this issue

Targeting cardiovascular risk in rheumatoid arthritis: a dual role for statins

Bisoendial et al.

Rheumatoid arthritis (RA) is increasingly recognized as a risk factor for cardiovascular disease, independent of the presence of classic cardiovascular risk factors such as smoking and obesity. In this article, the authors review the pathophysiology of accelerated atherosclerosis in RA, and discuss the potential role of statins in the reduction of both inflammation and atherosclerosis in these patients.